Naltrexone blocks the ability of opioids to eliminate pain and induce euphoria. This removes the rewarding aspects of opioid use that result in a desire for more. Reduced cravings make it easier for people not to use. Naltrexone does not help with withdrawal symptoms, and cannot be started until 7-10 days after the last opioid use. It is available in a long-acting injectable form that lasts 30 days. Due to decreased tolerance, overdose risk is high for people who use large amounts of opioids while taking naltrexone and for those who return to opioid use after a period of taking naltrexone.

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